My first trip was amazing; learned how to appreciate life in a completely different way, and a whole bunch of other wonderful things. Laughed for hours on end. Your mind set does have a lot to do with it, but if you just set your boundaries between knowing whats real and whats not, you should be fine. 

If you take large doses consistently within short periods of time, becoming perma-fried turns into a possibility, and might cause flash backs. Just remember to know your limits, and to keep the good vibes comin’. :)